Recombinant attenuated clostridium organisms and vaccine
US7732187B2 · kind B2 · utility
6Cited by
5References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 12, 2007 |
| Grant date | Jun 8, 2010 |
| Priority date | — |
| Expiry date | Jan 23, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/523
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.