Mass labels

US7732378B2 · kind B2 · utility

Assignee

• ELECTROPHORETICS LIMITED · GB

Inventors

• Andrew Hugin Thompson · Cambridge, GB
• Christian Hamon · Saint-Nazaire, FR
• Jurgen Schafer · Munich, DE
• Karsten Kuhn · Dortmund, DE
• Joseph Schwarz · Frankfurt, DE
• Thomas Neumann · Frankfurt am Main, DE

Key dates

• Filing date: Sep 16, 2002
• Grant date: Jun 8, 2010
• Expiry date: Sep 16, 2022

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2458/15
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Provided is a set of two or more mass labels, each label in the set comprising a mass marker moiety attached via a cleavable linker having at least one amide bond to a mass normalization moiety, wherein the aggregate mass of each label in the set may be the same or different and the mass of the mass marker moiety of each label in the set may be the same or different, and wherein in any group of labels within the set having a mass marker moiety of a common mass each label has an aggregate mass different from all other labels in that group, and wherein in any group of labels within the set having a common aggregate mass each label has a mass marker moiety having a mass different from that of all other mass marker moieties in that group, such that all of the mass labels in the set are distinguishable from each other by mass spectrometry, and wherein the mass marker moiety comprises an amino acid and the mass normalization moiety comprises an amino acid.