Patent · US Active

Process for preparing tetrahydrobiopterin and analogs of tetrahydrobiopterin

US7732599B2 · kind B2 · utility

13Cited by

0References

7Claims

0Family size

Assignees

BIOMARIN PHARMACEUTICAL INC. · US
Merck Eprova AG · CH

Inventors

Rudolf Moser · Schaffhausen, CH
Viola Groehn · Dachsen, CH
Andreas Schumacher · Weil am Rhein, DE
Pierre Martin · Rheinfelden, CH
Dirk Spielvogel · Lorsch, DE

Key dates

Filing date	Nov 17, 2004
Grant date	Jun 8, 2010
Priority date	—
Expiry date	Oct 6, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D475/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Process for the preparation of tetrahydrobiopterin from neopterin and/or 6-substituted pterins with an improved yield and a high stereoselectivity. Also disclosed herein are novel individual intermediates prepared in the preparation of tetrahydrobiopterin, such as selectively protected neopterin useful for the preparation of tetrahydrobiopterin.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.