Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
US7732616B2 · kind B2 · utility
22Cited by
13References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 17, 2006 |
| Grant date | Jun 8, 2010 |
| Priority date | — |
| Expiry date | Nov 21, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are compounds of the Formulas I and Vand pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.