Process for the preparation of enantiomerically enriched indoline-2-carboxylic acid
US7732621B2 · kind B2 · utility
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Key dates
| Filing date | Dec 22, 2005 |
| Grant date | Jun 8, 2010 |
| Priority date | — |
| Expiry date | Dec 22, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically enriched chiral ortho-X-substituted phenylalanine compound, wherein X is a leaving group, is subjected to cyclisation, preferably at a temperature of below about 140° C., upon formation of the enantiomerically enriched indoline-2-carboxylic acid compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.