Artificial dura mater and process for producing the same
US7736393B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 18, 2005 |
| Grant date | Jun 15, 2010 |
| Priority date | — |
| Expiry date | Jul 15, 2026 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/926
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Provided are an artificial dura mater having a laminated constitution of at least two layers of in vivo degradable polymers, at least one layer of them being a substrate layer, the substrate layer being formed of a lactic acid/glycolic acid/ε-caprolactone copolymer, the copolymer having a component molar ratio of 60-85:3-15:10-30 mol % and the copolymer having an average chain length that satisfies the following expressions (1) to (3) and a process for the production thereof, and when this artificial dura mater is used, no liquid leakage is caused since the bloating of suture holes is small, and the period of time for which it retains its strength is suitably a little longer than the period of time required for the regeneration of an autodura mater,2<L(LA)<[LA%/(LA%+GA%+CL%)]×X×0.058 (1)1<L(GA)<[GA%/(LA%+GA%+CL%)]×X×0.58 (2)1<L(CL)<[CL%/(LA%+GA%+CL%)]×X×0.58 (3)wherein L(LA), L(GA) and L(CL) represent average chain lengths of lactic acid units, glycolic acid units and of caprolactone units, LA%, GA% and CL% represent molar ratios of a lactic acid component, a glycolic acid component caprolactone component in the copolymer and X is a polymerization degree of the copolymer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.