Pharmaceutical composition comprising an immunoglobulin Fc region as a carrier
US7736653B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 13, 2004 |
| Grant date | Jun 15, 2010 |
| Priority date | — |
| Expiry date | Jun 3, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a novel use of an immunoglobulin Fc fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier remarkably extends the serum half-life of a drug while maintaining the in vivo activity of the drug at relatively high levels. Also, when the drug is a polypeptide drug, the pharmaceutical composition has less risk of inducing immune responses compared to a fusion protein of the immunoglobulin Fc fragment and a target protein, and is thus useful for developing long-acting formulations of various polypeptide drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.