Patent · US Active

Monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medical products

US7736863B2 · kind B2 · utility

4Cited by
3References
70Claims
0Family size

Inventors

Key dates

Filing dateDec 20, 2006
Grant dateJun 15, 2010
Priority date—
Expiry dateDec 22, 2026

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2800/7095
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.