Method and device for producing biochemical reaction supporting materials

US7737088B1 · kind B1 · utility

Assignee

• febit holding GmbH · DE

Inventors

• Cord Stahler · Weinheim, DE
• Peer Stahler · Mannheim, DE
• Manfred Muller · Berlin, DE
• Fritz Stahler
• Hans Lindner · Stuttgart, DE

Key dates

• Filing date: Aug 27, 1999
• Grant date: Jun 15, 2010
• Expiry date: Aug 27, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/973
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to arrays of biochemical and/or biofunctional elements such as nucleic acids (oligonucleotides, for example) or other biomolecules on a carrier surface and methods of producing such arrays using photoactivation of predetermined areas for synthesis using an illumination matrix that is computer-controlled to generate an exposure pattern. This exposure pattern can be adjusted and monitored by computer using a light sensor matrix, for example a CCD matrix, to allow precise, controlled illumination of specific regions and therefore attachment of array building blocks to those specific regions. The methods and compositions of the invention permit spatially resolved photochemical synthesis of polymer probes on a carrier.