Indole inhibitors of MDM2 and the uses thereof

US7737174B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Dongguang Qin · Auburn Hills, US
• Jiangyong Chen · Ann Arbor, US
• Shanghai Yu · Shanghai, CN

Key dates

• Filing date: Aug 30, 2007
• Grant date: Jun 15, 2010
• Expiry date: Aug 30, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).