Protein complex using an immunoglobulin fragment and method for the preparation thereof
US7737260B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 13, 2004 |
| Grant date | Jun 15, 2010 |
| Priority date | — |
| Expiry date | Aug 23, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active polypeptide, a non-peptide polymer and an immunoglobulin Fc fragment. Since the three components are covalently linked, the protein conjugate has extended in vivo duration and enhanced stability for the physiologically active polypeptide. The protein conjugate maintains the in vivo activity at relatively high levels and remarkably increases the serum half-life for the physiologically active polypeptide, with less risk of inducing undesirable immune responses. Thus, the protein conjugate is useful for developing long-acting formulations of various polypeptide drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.