Anomeric derivatives of monosaccharides

US7737287B2 · kind B2 · utility

Assignee

• Alchemia Limited · US

Inventors

• Wim Meutermans · Brisbane, AU
• Michael L. West · Brisbane, AU
• Thanh Le Giang · Cleveland, AU
• George Adamson · Yateley, GB
• Karl Schafer · Leverkusen, DE
• Giovanni Abbenante · Caboolture, AU

Key dates

• Filing date: Mar 28, 2003
• Grant date: Jun 15, 2010
• Expiry date: Jan 5, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.