Non-steroidal androgen receptor modulators, preparation process, pharmaceutical composition and use thereof

US7737288B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• Sichuan University · CN

Inventors

• Mingwei Wang · Longbeilingcun, CN
• Caihong Zhou · Shanghai, CN
• Xin Hui · Shanghai, CN
• Haoran Su · Shanghai, CN
• Jie Gao · Beijing, CN
• Yong Deng · Sichuan, CN
• Dacheng Yang · Sichuan, CN

Key dates

• Filing date: May 26, 2006
• Grant date: Jun 15, 2010
• Expiry date: Mar 1, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Non-steroidal androgen receptor modulating compounds of the general formula (I), their pharmaceutically acceptable salts, preparation process and pharmaceutically compositions containing the said compounds are disclosed. Such compounds of the general formula (I) or their pharmaceutically acceptable salts can be used for preparing non-steroidal medicines to treat and/or prevent conditions or diseases such as prostatic hyperplasia, prostate cancer, hirsutism, severe hormone-dependent alopecia or acne, etc. as a result of androgen receptor antagonistic activities.