Patent · US Active

Amide forming chemical ligation

US7737293B2 · kind B2 · utility

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16Claims

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Assignee

The Regents of the University of California · US

Inventors

Jeffrey Bode · Lompoc, US
Ryan Fox · Mississauga, CA

Key dates

Filing date	Nov 10, 2008
Grant date	Jun 15, 2010
Priority date	—
Expiry date	Nov 10, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K5/0815
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

An amide is formed by reacting an α-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof comprising a nitrogen covalently bound to an atom selected from oxygen, nitrogen, and sulfur. The amide bond is formed between the α-carbon of the ketoacid and the nitrogen of the amine. The α-ketoacid can be formed using a novel sulfur reagent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.