Biomarkers for aging
US7739056B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 24, 2009 |
| Grant date | Jun 15, 2010 |
| Priority date | — |
| Expiry date | Feb 24, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B50/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A statistical and functional correlation strategy to identify changes in cellular pathways specifically linked to impaired cognitive function with aging. Analyses using the strategy identified multiple groups of genes expressed in the hippocampi of mammals, where the genes were expressed at different levels for several ages. The aging changes in expression began before mid-life. Many of the genes were involved in specific neuronal and glial pathways with previously unrecognized relationships to aging and/or cognitive decline. These identified genes and the proteins they encode can be used as novel biomarkers of brain aging and as targets for developing treatment methods against age-related cognitive decline, Alzheimer's Disease and Parkinson's Disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.