Enhanced oral and transcompartmental delivery of therapeutic or diagnostic agents

US7740882B2 · kind B2 · utility

Inventors

• Srinivasan Ramanathan · Mountain View, US
• Stanley Stein · East Brunswick Township, US
• Michael Leibowitz · Manalapan, US
• Patrick J. Sinko · Lebanon, US
• Tamara Minko · Edison, US
• Gregory Williams · Bernardsville, US
• Goubao Zhang · San Diego, US
• Xiaoping Zhang · Hunan, CN
• Shahrair Pooyan · Mount Kisco, US
• Seong Hee Park · Piscataway, US
• Bo-Xing Qiu · East Brunswick Township, US
• Pankaj Paranjpe · Piscataway, US

Key dates

• Filing date: Jun 29, 2005
• Grant date: Jun 22, 2010
• Expiry date: Mar 17, 2028

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.