Patent · US Active

Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof

US7741277B2 · kind B2 · utility

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2Claims

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Assignee

Aeterna Zentaris, Inc. · DE

Inventors

Eckhard Guenther · Maintal, DE
Olaf Schaefer · Biberach an der Riß, DE
Michael Teifel · Weiterstadt, DE
Klaus Paulini · Maintal, DE

Key dates

Filing date	Sep 6, 2007
Grant date	Jun 22, 2010
Priority date	—
Expiry date	Jan 19, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K14/6555
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.