Patent · US Active

Non-standard nucleobases implementing the isocytidine and isoguanosine hydrogen bonding patterns

US7741294B1 · kind B1 · utility

6Cited by
3References
3Claims
0Family size

Inventor

Key dates

Filing dateMar 9, 2006
Grant dateJun 22, 2010
Priority date—
Expiry dateAug 25, 2028

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2320/52
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

This invention provides compositions of matter that, when incorporated into an oligonucleotide, present to a complementary strand in a Watson-Crick pairing geometry a pattern of hydrogen bonds that is different from the pattern presented by adenine, guanine, cytosine, and thymine. Most specifically, this invention discloses and claims compositions of matter that present the same hydrogen bonding patterns as the isocytidine and isoguanosine nucleobases, but do not have unfavorable tautomeric forms, do not become disassociated from their sugar, and do not make major groove interactions, as much, as easily, or as strongly as isocytidine and isoguanosine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.