Methods of using nucleic acid vector-lipid complexes

US7741300B2 · kind B2 · utility

Assignee

• National Jewish Medical and Research Center · US

Inventors

• Steven W. Dow · Fort Collins, US
• Robyn E. Elmslie · Littleton, US
• Jurgen Karl Johannes Schwarze · Witten, DE
• Erwin Gelfand · Englewood, US

Key dates

• Filing date: Dec 27, 2005
• Grant date: Jun 22, 2010
• Expiry date: Apr 22, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18834
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to a vaccine and a method for immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, an infectious disease, or a condition associated with a deleterious activity of a self-antigen. Also disclosed are therapeutic compositions useful in such a method.