DBAIT and uses thereof

US7741308B2 · kind B2 · utility

Assignees

• INSTITUT CURIE · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• MUSEUM NATIONAL D'HISTOIRE NATURELLE · FR
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

• Marie Dutreix · L'Haÿ-les-Roses, FR
• Jian Sun · Saint-Maur-des-Fossés, FR

Key dates

• Filing date: Nov 26, 2008
• Grant date: Jun 22, 2010
• Expiry date: Nov 26, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules. that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair.The invention discloses the use of these molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumor cell nuclei in order to neutralize transiently their DNA repair capacity and trigger their death.