Biological low-molecular-weight derivatives
US7741454B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 11, 2003 |
| Grant date | Jun 22, 2010 |
| Priority date | — |
| Expiry date | Apr 6, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/46
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.