Chimeric receptor genes and cells transformed therewith
US7741465B1 · kind B1 · utility
270Cited by
5References
20Claims
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Key dates
| Filing date | Jul 2, 1993 |
| Grant date | Jun 22, 2010 |
| Priority date | — |
| Expiry date | Jul 2, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/03
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.