Process for preparing Valsartan

US7741507B2 · kind B2 · utility

Assignee

• Alembic Ltd. · IN

Inventors

• Rohit Ravikant Soni · Salumbar, IN
• Sanjay Lakhabhai Vasoya · Sayla, IN
• Ravindra Charudatta Ghotikar · Vadodara, IN
• Anand Kumar Pandey · Vadodara, IN
• Hetal Remeshchandra Shah · Vadodara, IN

Key dates

• Filing date: Jul 24, 2006
• Grant date: Jun 22, 2010
• Expiry date: Nov 20, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C255/58
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel compound of formula (IV), which is an organic acid salt of N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine ester. This compound is an useful intermediate for process of preparation of Valsartan of formula (I), chemically known as (S)—N-(1-Carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2′-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]amine. This invention also relates to a process for preparing Valsartan using novel intermediate of formula (IV).