Enhancement of the immune response for vaccine and gene therapy applications
US7744900B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 29, 2008 |
| Grant date | Jun 29, 2010 |
| Priority date | — |
| Expiry date | Apr 29, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Expression cassettes are provided comprising a promoter operably linked to a nucleic acid molecule which, when transcribed in vivo, forms double-stranded RNA that induces the production of interferon. Expression cassettes also are provided comprising a promoter operably linked to a ribozyme or antisense nucleic acid molecule which, when transcribed in vivo, forms a ribozyme or antisense RNA molecule that stimulates an immune response. In addition, expression cassettes are provided comprising a promoter operably linked to a ribozyme or antisense nucleic acid molecule which, when transcribed in vivo, stimulates apoptosis. Finally, gene delivery vectors are provided which contain such expression cassettes, host cells containing the gene delivery vectors, and methods of utilizing the expression cassettes, gene delivery vectors, and host cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.