Method for precipitation of small medicament particles into use containers
US7744923B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 11, 2007 |
| Grant date | Jun 29, 2010 |
| Priority date | — |
| Expiry date | Oct 11, 2027 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Commercially feasible methods for lyophobic precipitation of liquid-dispersed or dissolved material (e.g., medicaments) are provided wherein a plurality of individual, open containers (22) each containing a quantity (84) of a solution or dispersion are treated within a common pressurizable chamber (12). In this process, desired near-supercritical or supercritical temperature and pressure conditions are established for a selected antisolvent gas such as carbon dioxide, and an ultrasonic device (14) is actuated to generate high energy ultrasonic waves in the chamber (12). This leads to intense mixing of the antisolvent with the liquid solution or dispersion within the containers (22), with consequent solvent removal and material precipitation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.