Synthesis of nanoassemblies containing luminescent quantum dots and magnetic nanoparticles

US7745001B2 · kind B2 · utility

Assignee

• University of New Orleans Research and Technology Foundation, Inc. · US

Inventors

• Zeev Rosenzweig · New Orleans, US
• Yongfen Chen · Eugene, US
• Desheng Wang · Pasadena, US

Key dates

• Filing date: Mar 23, 2005
• Grant date: Jun 29, 2010
• Expiry date: Jan 9, 2027

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2998
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Negatively charged luminescent CdSe—ZnS quantum dots (QDs) were successfully incorporated into novel luminescent glyconanospheres averaging around 190 nm in diameter through electrostatic interactions with carboxymethyldextran (CM-dextran) and polylysine. The glyconanospheres preferably contain as well carboxyl-modified iron oxide nanocrystals. In addition to electrostatic attraction between the negatively charged dextran, the negatively charged CdSe—ZnS QDs (and negatively charged iron oxide nanocrystals, if present), and the positively charged polylysine, covalent amide bonds were introduced to cross link the QDs (and negatively charged iron oxide nanocrystals, if present) with the polysaccharide matrix to further stabilize the glyconanospheres. The dextran residues on the surface of the nanospheres show high affinity toward the glucose binding protein-Concanavalin A (Con A). As a result, these luminescent CdSe—ZnS QD incorporated glyconanospheres are a useful tool for studying carbohydrate-protein interactions that are critical steps in bacterial and viral infection.