Comparative genomic resequencing
US7745118B2 · kind B2 · utility
10Cited by
4References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 8, 2005 |
| Grant date | Jun 29, 2010 |
| Priority date | — |
| Expiry date | Jun 16, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/795
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is an improved method of resequencing DNA using microarrays to rapidly map and identify SNPs, deletions and amplification events present in the genome of an organism. The method is performed by hybridizing a reference and a test genome to two separate arrays with each array exhibiting a specific intensity pattern. The intensity differences between the reference and the test genome arrays are used to produce a mutation map. The mapped differences are resequenced on a set of resequencing arrays to identify specific genetic mutations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.