Cell culture and method for screening for a compound useful in the treatment or prevention of hepatic cirrhosis
US7745120B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Dec 12, 2005 |
| Grant date | Jun 29, 2010 |
| Priority date | — |
| Expiry date | Mar 30, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/085
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a cell-culturing model and a method for screening compounds which can be applied in treating or preventing hepatic cirrhosis. The cell culturing model comprises a population of hepatocytes and hepatic stellate cells (HSCs) derived from co-culturing, and at least one population of the cells comprises a nucleotide sequence fragment of a reporter gene and a cell specific regulatory sequence. The cell-culturing model of the present invention can be applied in high throughput screening for effective compounds of medication, and also in understanding the functional mechanism of the effective compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.