Peptides of the AT1 receptor and their uses

US7745139B1 · kind B1 · utility

Assignee

• Max Delbrück-Centrum Für Molekulare Medizin · DE

Inventors

• Gerd Wallukat · Berlin, DE
• Volker Homuth · Bad Schandau, DE
• Friedrich Luft · Schwanebeck, DE

Key dates

• Filing date: Dec 22, 1999
• Grant date: Jun 29, 2010
• Expiry date: Dec 22, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K39/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are peptides of the AT1 receptor and their use for eliminating specifically binding, cell-physiologically active, pathological antibodies in preeclampsia and malign hypertension. The peptides may, for example, be used for the diagnosis of preeclampsia. Peptides having the sequence AFHYESQ (SEQ ID NO: 1), AVHYQSN (SEQ ID NO: 2), SHFYQTR (SEQ ID NO: 3), GYYFDTN (SEQ ID NO: 4) or ENTNIT (SEQ ID NO: 5) are preferred.