Patent · US Active

Monomethylvaline compounds capable of conjugation to ligands

US7745394B2 · kind B2 · utility

149Cited by

58References

44Claims

0Family size

Assignee

SEATTLE GENETICS, INC. · US

Inventors

Svetlana O. Doronina · Snohomish, US
Peter D. Senter · Seattle, US
Brian E. Toki · Shoreline, US
Allen Ebens · Redwood City, US
Toni Kline · Seattle, US
Paul Polakis · Mill Valley, US
Mark Sliwkowski · Redwood City, US
Susan D. Spencer · Tiburon, US

Key dates

Filing date	Aug 3, 2007
Grant date	Jun 29, 2010
Priority date	—
Expiry date	May 5, 2028

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10T428/13
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.