4-Amino-5-oxo-8-phenyl-5H-pyrido(2,3-D) pyrimidine derivatives as tyrosine kinase and raf kinase inhibitors for the treatment of tumours

US7745434B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Guenter Hoelzemann · Seeheim-Jugenheim, DE
• Karl-August Ackermann · Ober-Ramstadt, DE
• Helene Crassier · Darmstadt, DE
• Alfred Jonczyk · Darmstadt, DE
• Wilfried Rautenberg · Reinheim, DE
• Gema Tarrason · Barcelona, ES
• Elisabet Rosell-Vives · Barcelona, ES
• Jaume Adan · Mataró, ES
• Claudia Cases · Barcelona, ES

Key dates

• Filing date: Oct 20, 2005
• Grant date: Jun 29, 2010
• Expiry date: Sep 2, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I), in which R6, R7, R8, R9, Het1, X and X′ have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.