Urokinase inhibitors

US7745441B1 · kind B1 · utility

Assignee

• Wilex AG · DE

Inventors

• Peter Wikström · Gipf-Oberfrick, CH
• Helmut Vieweg · Rheinfelden (Baden), DE
• Jörg Stürzebecher · Erfurt, DE

Key dates

• Filing date: Sep 18, 1998
• Grant date: Jun 29, 2010
• Expiry date: May 30, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New urokinase inhibitors having a triisopropylphenylsulfonyl residue as an Nα-substituent for 3-amidinophenylalanine are provided. The introduction of the triisopropylphenylsulfonyl residue greatly increases the affinity of the compounds to urokinase and, thereby, increases their inhibitory activity against urokinase. These urokinase inhibitors are useful in determining the role of urokinase and urokinase receptor in various diseases, particularly in tumor propagation and metastasis. Methods of treating tumors and a pharmaceutical composition are also provided.