Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof
US7745465B2 · kind B2 · utility
Assignee
Inventors
- Laszlo Vigh
- Peter Nagy
- Jeno Szilbereky
- Laszlo Urogdi
- Andrea Jednakovits
- Laszlo Jaszlits
- Katalin Biro
- Ede Marvanyos
- Mihály Barabás
- Erzsébet Hegedüs
- László Korányi
- Mária Kürthy
- Gabor Balogh
- Ibolya Horváth
- Zsolt Török
- Éva Udvardy
- György Dormán
- Dénes Medzihradszky
- Bea Mézes
- Eszter Kovács
- Ernö Duda
- Beatrix Farkas
- Attila Glatz
Key dates
| Filing date | Jul 10, 2003 |
| Grant date | Jun 29, 2010 |
| Priority date | — |
| Expiry date | Nov 12, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II).The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.