Derivatives of 1,2-benzisoxazole-3-methane sulfonic acid as novel intermediates for the synthesis of zonisamide

US7745471B2 · kind B2 · utility

Assignee

• Chemagis Ltd. · IL

Inventors

• Vladimir Naddaka · Netanya, IL
• Eyal Klopfer · Nes Ziona, IL
• Shady Saeed · Haifa, IL
• Oded Arad · Rehovot, IL
• Joseph Kaspi · Givatayim, IL

Key dates

• Filing date: Jun 16, 2005
• Grant date: Jun 29, 2010
• Expiry date: Apr 29, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D261/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Derivatives of 1,2-benzisoxazole-3-methanesulfonic acid, which are non-hygroscopic and non-hydrated and their use as intermediates from the preparation of zonisamide are disclosed. Further disclosed are processes of preparing zonisamide from these 1,2-benzisoxazole-3-methanesulfonic acid derivatives, processes of preparing exemplary 1,2-benzisoxazole-3-methanesulfonic acid derivatives and crystalline forms of exemplary 2-benzisoxazole-3-methanesulfonic acid derivatives. A novel process of preparing zonisamide is also disclosed.