Beta-secretase modulators and methods of use

US7745484B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Wenge Zhong · Thousand Oaks, US
• Stephen Hitchcock · San Diego, US
• Brian K. Albrecht · Cambridge, US
• Michael D. Bartberger · West Hollywood, US
• James Brown · Moorpark, US
• Ryan Brown · Watertown, US
• Stuart C. Chaffee · Philadelphia, US
• Yuan Cheng · Newbury Park, US
• Michael Croghan · Thousand Oaks, US
• Russell Graceffa · Hampton, US
• Scott Harried · Calabasas, US
• Dean Hickman · Moorpark, US
• Dan Horne · Thousand Oaks, US
• Randall W. Hungate · Lansdale, US
• Ted Judd · San Fernando, US
• Matthew Kaller · Ventura, US
• Charles Kreiman · Watertown, US
• Daniel La · Brookline, US
• Patricia Lopez · Calabasas, US
• Craig E. Masse · Cambridge, US
• Holger Monenschein · San Diego, US
• Thomas Nguyen · Newbury Park, US
• Thomas Nixey · Newbury Park, US
• Vinod F. Patel · Acton, US
• Lewis D. Pennington · Ventura, US
• Matthew Weiss · Boston, US
• Qiufen Xue · Thousand Oaks, US
• Bryant Yang · Simi Valley, US

Key dates

• Filing date: Nov 10, 2006
• Grant date: Jun 29, 2010
• Expiry date: Sep 30, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/052
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula Iwherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.