Patent · US Active

Compositions and methods for inhibition of phospholipase A2 mediated inflammation

US7745489B2 · kind B2 · utility

0Cited by

2References

12Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Edward A. Dennis · Village of La Jolla, US
Tony L. Yaksh · San Diego, US
Karin Lucas · Encinitas, US
Camilla Svensson · San Diego, US
David A. Six · Durham, US
George Kokotos · Athens, GR
Violetta Constantinou-Kokotou · Athens, GR

Key dates

Filing date	Mar 7, 2003
Grant date	Jun 29, 2010
Priority date	—
Expiry date	Apr 17, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D309/30
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Specific, highly potent 2-oxo-amide based inhibitors of phospholipase A2 (PLA2) activity are provided. A role for PLA2 activity in spinally mediated inflammatory processes is established, and a method for treating hyperalgesia and other inflammatory conditions associated with PLA2 activity is provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.