Multi-arm cyclic or cubic siloxane-based formulations for drug delivery
US7745547B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Aug 7, 2006 |
| Grant date | Jun 29, 2010 |
| Priority date | — |
| Expiry date | Dec 13, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08L2203/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides multi-arm siloxane-based molecules suitable for use as a drug delivery vehicle comprising a central core molecule that comprises a cyclic or cubic siloxane, and a plurality of arms attached to the central core molecule, wherein each arm comprises an organic moiety. The multi-arm siloxane-based molecules described herein are suitable for encapsulation of a therapeutic agent. The invention further includes pharmaceutical compositions comprising the claimed multi-arm siloxane-based molecules and an encapsulated therapeutic agent in combination with a pharmaceutically acceptable carrier. Methods of making and using the multi-arm siloxane-based molecules are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.