Anti-myostatin antibodies

US7745583B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Bomie Han · Carmel, US
• Andrew Ihor Korytko · Oceanside, US
• Pamela Jean Mitchell · Indianapolis, US
• Rosamund Carol Smith · Greenfield, US
• Linda O'Bryan (Nee Tobias) · Indianapolis, US
• Rong Wang · Mianyang, CN

Key dates

• Filing date: Nov 4, 2009
• Grant date: Jun 29, 2010
• Expiry date: Nov 4, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/582
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing hone density, or for the treatment of various disorders in mammalian and avian species.