Non-invasive systems and methods for the determination of cardiac injury using a characterizing portion of a voxel histogram

US7747308B2 · kind B2 · utility

Assignee

• Wake Forest University Health Sciences · US

Inventors

• William Gregory Hundley · Winston-Salem, US
• Craig A. Hamilton · Lewisville, US
• Kimberly Lane · Advance, US
• Tim Morgan · Pittsburgh, US
• Frank Torti · Palo Alto, US
• Ralph B. D'Agostino · Winston-Salem, US

Key dates

• Filing date: Feb 2, 2006
• Grant date: Jun 29, 2010
• Expiry date: Oct 4, 2028

Classification

• Technology area (CPC G): Physics
• CPC primary: G06V2201/03
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Methods, systems and circuits predict cardiotoxicity induced cardiac injury prior to an irreversible state by electronically generating at least one histogram of mean intensities of voxels/pixels in an MRI image of a left ventricle myocardium and electronically determining a likelihood of cardiac injury due to cardiotoxicity based on data from the at least one histogram.