Methods of gene transfer to astrocytes with mokola virus pseudotyped lentivirus vectors

US7749973B2 · kind B2 · utility

Assignee

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR

Inventors

• Chamsy Sarkis · Paris, FR
• Yi He · Chengdu, CN
• Che Serguera · Paris, FR
• Noelle Dufour · Mennecy, FR
• Jacques Mallet · Paris, FR

Key dates

• Filing date: May 31, 2002
• Grant date: Jul 6, 2010
• Expiry date: Jun 3, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/20122
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a defective lentivirus which is pseudotyped with a lyssavirus envelope of the PV (rabies virus) or MOK type (Mokola virus), for example, and to the use thereof, especially in the preparation of a composition for in vivo transfer of genes in astrocytes and also for the treatment of disorders of the central nervous system.