Patent · US Active

Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors

US7750007B2 · kind B2 · utility

79Cited by

0References

9Claims

0Family size

Assignee

Supergen, Inc. · US

Inventors

David J. Bearss · Alpine, US
Xiao-Hui Liu · Holladay, US
Hariprasad Vankayalapati · Draper, US
Yong Xu · Midvale, US

Key dates

Filing date	Nov 6, 2007
Grant date	Jul 6, 2010
Priority date	—
Expiry date	Dec 12, 2027

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II):or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.