Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same

US7750019B2 · kind B2 · utility

Assignee

• KOWA COMPANY, LTD. · JP

Inventors

• Tadaaki Ohgiya · Tokorozawa, JP
• Toru Miura · Higashimurayama, JP
• Ayumu Okuda · Higashimurayama, JP
• Toshiharu Arai
• Koichi Yamazaki · Tokyo, JP
• Taro Aoki · Tokorozawa, JP
• Katsutoshi Miyosawa · Higashimurayama, JP
• Haruki Shibata · Tokyo, JP
• Kimiyuki Shibuya · Saitama, JP

Key dates

• Filing date: Aug 7, 2007
• Grant date: Jul 6, 2010
• Expiry date: Dec 5, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound represented by the following general formula (I) or a salt thereof, or a solvate thereof:(wherein R1, R2, R3, R4 and R5 are the same or different, and represent hydrogen atom, a halogen atom, a lower alkyl group etc., R6, R7 and R8 are the same or different, and represent hydrogen atom, a halogen atom, a lower alkyl group etc., R9 and R10 are the same or different, and represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group etc., and R11 represents hydrogen atom, a halogen atom, a lower alkoxy group, a (lower alkyl)thio(lower alkoxy) group, a (lower alkyl)sulfinyl(lower alkoxy) group, a (lower alkyl)sulfonyl(lower alkoxy) group etc.), which has potent inhibitory activity on CETP.