Mucosal vascular addressins
US7750137B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 1, 1995 |
| Grant date | Jul 6, 2010 |
| Priority date | — |
| Expiry date | Aug 24, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to isolated and/or recombinant nucleic acids which encode naturally occurring primate MAdCAMs, wherein said nucleic acid encodes the polypeptide shown in FIG. 1 (SEQ ID NO:2), the polypeptide shown in FIG. 2 (SEQ ID NO:4), or the polypeptide shown in FIG. 3 (SEQ ID NO:6). The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a naturally occurring primate MAdCAM, wherein said nucleic acid encodes a polypeptide having an amino acid sequence as set forth in FIG. 1 (SEQ ID NO:2), FIG. 2 (SEQ ID NO:4), or FIG. 3 (SEQ ID NO:6); to host cells comprising such constructs, useful for the production of recombinant proteins; the use of nucleic acids and/or proteins in assays to identify inhibitors (e.g., antagonists) of primate MAdCAM function; and to antibodies reactive with primate MAdCAM, which are useful in in vitro methods, diagnostic and/or therapeutic applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.