Methods and compositions for enhancing the efficacy and specificity of RNA silencing
US7750144B2 · kind B2 · utility
149Cited by
1References
36Claims
0Family size
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Key dates
| Filing date | Aug 4, 2004 |
| Grant date | Jul 6, 2010 |
| Priority date | — |
| Expiry date | Nov 28, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.