Intermediate compounds for making dihydropteridinones useful as pharmaceutical compositions and processes of making the same

US7750152B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Matthias Hoffman · Mittelbiberach, DE
• Matthias Grauert · Ingelheim am Rhein, DE
• Trixi Brandl · Biberach, DE
• Steffen Breitfelder · Aßmannshardt, DE
• Christian Eickmeier · Mittelbiberach, DE
• Martin Steegmaier · Wien, AT
• Gisela Schnapp · Biberach an der Riß, DE
• Anke Baum · Alland, AT
• Jens Quant · Guntramsdorf, AT
• Flavio Solca · Wien, AT
• Florian Colbatzky · Stafflangen, DE

Key dates

• Filing date: Nov 16, 2007
• Grant date: Jul 6, 2010
• Expiry date: Nov 16, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D475/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are dihydropteridinones of general formula (I)wherein the groups L and R1-R5 have the meanings given in the claims and specification, the pharmaceutical compositions, isomers, intermediates thereof and processes for preparing these dihydropteridinones. The compounds are useful the treatment and/or prevention of cancer, infections, inflammatory and autoimmune diseases.