Process for preparation of nonnatural amino acid and intermediate thereof
US7750162B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 18, 2005 |
| Grant date | Jul 6, 2010 |
| Priority date | — |
| Expiry date | Sep 29, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of a nonnatural amino acid represented by the following formula (C):which is characterized by reacting a compound represented by the following formula (A1), a compound represented by the following formula (A2) and a compound represented by the following formula (A3) (step 1):to form a compound represented by the following formula (B):and then subjecting the compound (B) to deprotection of protective groups of carboxyl groups and to decarboxylation (wherein X1 and X2 are a leaving group, R1 is an aromatic group, an unsaturated heterocyclic group, or R6CO group, R2 and R3 are a protected carboxyl group, R4 is a protected amino group, R5 is hydrogen atom, an aliphatic hydrocarbon group, an aromatic group, or a heterocyclic group, R6 is an aromatic group or an unsaturated heterocyclic group, etc., and p, q and r are an integer of 0 to 10).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.