Patent · US Active

Alleles of the rel gene from coryneform bacteria

US7754446B2 · kind B2 · utility

5Cited by

4References

10Claims

0Family size

Assignee

EVONIK DEGUSSA GMBH · DE

Inventors

Brigitte Bathe · Salzkotten, DE
Caroline Kreutzer · Melle, DE
Georg Thierbach · Bielefeld, DE

Key dates

Filing date	Oct 16, 2007
Grant date	Jul 13, 2010
Priority date	—
Expiry date	Jan 21, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P13/04
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having GTP-pyrophosphate kinase enzyme activity, a vector comprising the isolated polynucleotide, a recombinant microorganism comprising the vector, and a process for preparing the recombinant coryneform bacterium is described. A method for over-expressing a GTP-pyrophosphate kinase, a method of preparing an L-amino acid, an L-lysine comprising and L-tryptophan comprising feed is also described.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.