Method of using retro inverso peptides derived from leukemia inhibitory factor
US7754690B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Aug 9, 2006 |
| Grant date | Jul 13, 2010 |
| Priority date | — |
| Expiry date | Sep 1, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/5415
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods of treatment using retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence that is retro-inverso with respect to SEQ ID NO: 1. The peptides of the invention have the same activity as native LIF and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.