Patent · US Active

4-phenylpiperidine derivatives as renin inhibitors

US7754727B2 · kind B2 · utility

1Cited by

5References

9Claims

0Family size

Assignee

Novartis AG · CH

Inventors

Richard Sedrani · Basel, CH
Juergen Klaus Maibaum · Basel, CH
Werner Breitenstein · Basel, CH
Holger Sellner · Buchs, CH
Claus Ehrhardt · Lörrach, DE
Nils Ostermann · Binzen, DE

Key dates

Filing date	Jun 27, 2008
Grant date	Jul 13, 2010
Priority date	—
Expiry date	Jul 14, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D409/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds of the present invention having the formula (I) exhibit inhibitory activity on the natural enzyme renin. Thus, compounds of formula (I) may be employed for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.