Spirocyclic anti-migraine compounds
US7754732B2 · kind B2 · utility
10Cited by
7References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 5, 2007 |
| Grant date | Jul 13, 2010 |
| Priority date | — |
| Expiry date | Aug 20, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2807
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compounds of Formula (I)as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.